Psilocybin-Assisted Therapy in Denver
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Our physician-directed psilocybin program includes structured preparation, guided sessions, and integration to support neuroplasticity, emotional healing, and lasting positive change.
✓ Individual and group programs available.
FREE ConsultWhat's included with Psilocybin-Assisted Therapy?
- Personalized Screening: We begin by getting to know you, your health history, and your goals to ensure that psilocybin therapy is appropriate, safe, and aligned with your needs.
- Guided Sessions with Professional Oversight: Each experience is carefully facilitated by trained clinicians who provide support, reassurance, and expert guidance throughout the process.
- Integration Support: After each session, we work with you to explore your experiences, helping translate insights into practical tools for emotional clarity, cognitive flexibility, and sustained personal growth.
About Psilocybin-Assisted Therapy
With growing research and clinical evidence, psilocybin is showing promising potential in supporting individuals with depression, anxiety, trauma, emotional burnout, and end-of-life distress, while also supporting neuroplasticity, emotional resilience, mental clarity, and cognitive health.
Whether you're seeking relief from persistent symptoms or pursuing personal growth, our experienced team provides evidence-informed care with structured preparation, guided sessions, and integration tailored to your individual needs.
Why Choose Us
As Denver's first physician-directed healing center, our team combines advanced training in psychiatry, integrative medicine, and neuroscience with a deep commitment to patient-centered care. We take pride in providing a safe, professional, and welcoming environment where every individual is treated with respect, empathy, and thoughtful guidance.
At PICMI, psilocybin-assisted therapy is a clinically guided journey designed to support healing, self-understanding, and meaningful transformation, all while meeting the highest medical and regulatory standards.
Whether you are exploring therapy for the first time or seeking innovative cognitive or mental health solutions, our Denver-based team is here to walk alongside you with expertise, compassion, and care.
Meet Your Care Team
Lynn Welch Puana, MD
Founder & Medical Director,
Premier Integrative & Cognitive
Medical Institute
Amir Mahmoud, NP, PMHNP-BC
Psychiatry Director,
Psychiatric-Mental Health
Nurse Practitioner
Nedjet Fenix, DNP, CNM
Licensed Facilitator
John Manasjan, FP-C, NREMT-P
Licensed Psychedelic Facilitator
Adolphus Love, LMT
EEG Technician
Frequently Asked Questions
- Is psilocybin therapy legal in Denver?Yes—psilocybin therapy is permitted in Colorado under Proposition 122, approved in 2022. Denver was an early leader in allowing psilocybin use, and licensed healing centers began opening in 2024. Today, sessions take place in a safe, regulated setting with trained, licensed providers.
- Who is eligible for psilocybin-assisted therapy at PICMI Denver?Adults experiencing mood, trauma, or cognitive challenges may be considered for psilocybin-assisted therapy. Eligibility is determined through a thorough medical and mental health screening to ensure safety, suitability, and alignment with your treatment goals.
- What conditions can psilocybin-assisted therapy help treat?Psilocybin therapy has shown promise in supporting treatment-resistant depression, anxiety disorders, PTSD, obsessive-compulsive or rigid thought patterns, and certain substance use challenges. It can also support personal growth, emotional resilience, and cognitive flexibility under professional guidance.
- How is psilocybin therapy different from traditional mental health treatments?Unlike daily medications or standard therapy alone, psilocybin-assisted therapy provides a focused, experiential approach that temporarily increases neural flexibility. This state allows individuals to explore emotions, trauma, or thought patterns in a deep, guided way, creating opportunities for lasting cognitive and emotional change.
- What safety measures are in place during psilocybin-assisted therapy at PICMI?Safety is a top priority at PICMI. All sessions are supervised by trained, licensed providers with medical oversight. We conduct personalized screening, monitor vital signs during sessions, and provide psychological support throughout to ensure a safe, structured experience.
- What is integration therapy and why is it important after psilocybin sessions?Integration therapy helps translate insights gained during psilocybin sessions into practical, lasting change. Our clinicians guide patients through reflective exercises, coping strategies, and emotional processing to reinforce resilience, cognitive flexibility, and overall mental wellness.
- How do group psilocybin sessions work?Group programs are offered on pre-scheduled dates, typically over a weekend, making them ideal for individuals traveling from out of town. Group programs can be powerful because they reduce isolation and foster stronger connection, offer healing through shared experience, provide supportive group accountability, come with more accessible pricing, and allow for efficient travel scheduling for non-local clients.
Psilocybin Therapy: Research & News
Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report
A 2026 Frontiers in Neuroscience case report documented unexpected cognitive and functional gains across multiple domains in a patient with advanced Alzheimer's disease after administration of high-dose psilocybin-containing mushrooms — raising new questions about neuroplasticity and psilocybin's potential relevance to neurodegenerative conditions.
Investigating the safety and tolerability of single-dose psilocybin for post-traumatic stress disorder: A nonrandomized open-label clinical trial
This 2025 nonrandomized open-label trial examined psilocybin's safety profile in adults living with post-traumatic stress disorder. Results indicated the treatment was well-tolerated at a single dose, lending early clinical support for continued investigation into psilocybin as a PTSD intervention.
Therapeutic Use of Psilocybin in Depression: a Systematic Review of Clinical Evidence
A systematic review from researchers at the Central Institute of Mental Health in Mannheim, published in Acta Neuropsychiatrica, found that one or two psilocybin sessions paired with psychological support produced antidepressant effects that held for weeks to months. Across structured clinical settings, the compound demonstrated a strong tolerability profile.
Our Care Process
Achieve clarity and confidence through personalized guidance. Your journey is designed to optimize brain function and empower meaningful change.
- 01
Health Check & Medical Approval
Meet with a physician and complete any necessary lab work to ensure treatment is safe for you.
- 02
Personalized Treatment Plan
Your doctor designs a care plan tailored to your needs and goals.
- 03
Follow-Up & Continued Support
We stay connected to monitor your progress, ensure safety, and help you integrate your experience.
Convenient Location, Parking & Comfortable Care Environment
Our clinic is designed for ease, privacy, and comfort from the moment you arrive. Patients benefit from convenient on-site parking, elevator access, and quiet, climate-controlled treatment spaces. Use the map to plan your visit and experience a setting built to support focused, uninterrupted care.
Complimentary Consultation
Speak with a member of our clinical team to discuss your symptoms, goals, and whether a comprehensive evaluation is the right next step. This brief, no-obligation consult is designed to provide clarity and direction.