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Psilocybin Therapy in Denver

Beyond Medication. Beyond Talk Therapy.Discover Psilocybin.

A physician-guided experience designed to identify the root cause of what's holding you back, gain new perspective, and create meaningful, lasting change.

Schedule Your Discovery Call

Complimentary|No Obligation
  • Board-Certified Physicians
  • Evidence-Based Approach
  • Personalized Treatment Plans

Psilocybin is more than a treatment—it's a catalyst.

In the right setting, it can help your brain create new pathways for healing, clarity, and growth.

What is Psilocybin-Assisted Therapy?

Psilocybin-assisted therapy combines the therapeutic potential of psilocybin with personalized preparation, professional guidance, and integration support. In a safe, structured setting, psilocybin may temporarily shift perception and thought patterns, creating an opportunity to explore emotions, gain new perspectives, and work toward meaningful change with the support of an experienced care team.

Benefits of Psilocybin-Assisted Therapy

Psilocybin-assisted therapy may help create new perspectives and support meaningful change when combined with professional preparation and integration. Potential benefits may include:

  • Greater Emotional Awareness - Explore emotions, experiences, and thought patterns from a new perspective.

  • Reduced Symptoms - Research suggests potential benefits for depression, anxiety, PTSD, and other mental health challenges.

  • Increased Psychological Flexibility - Develop greater openness to new perspectives and ways of responding to challenges.

  • Personal Growth - Gain insights that may support positive changes in relationships, habits, and everyday life.

  • Lasting Change - Integration and continued support can help translate meaningful experiences into practical, sustainable changes.

A group psilocybin program in session at Premier Cognitive

Is Psilocybin-Assisted Therapy Right for You?

  • You’ve tried medications or therapy without lasting relief
  • You feel stuck, numb, or disconnected
  • Anxiety, depression, or trauma continue to return
  • You’re ready for a deeper level of healing
  • You want physician-guided care in a safe environment
Take the first step—Discovery Call
EEG software showing results for before and after psilocybin therapy

Your Journey With Psilocybin-Assisted Therapy

  1. 1. Discovery Call

    We learn about you, your goals, and if psilocybin therapy is right for you.

  2. 2. Medical Evaluation

    Review your health history and medications to ensure safety.

  3. 3. Preparation

    Personalized sessions to prepare you for the experience.

  4. 4. Guided Psilocybin Experience

    Experience psilocybin in a safe, supportive environment.

  5. 5. Integration

    Process insights and apply them to daily life.

  6. 6. Ongoing Support

    Continued care to support long-term growth and well-being.

Our Psilocybin Programs

Personalized. Physician-Led. Transformative.

Group Experience

Price: $2,499

A supportive, community-based experience. We hold sessions the first of every month.

  • Screening
  • 2 Preparation Sessions
  • 1 Psilocybin Session
  • IV Hydration
  • 2 Integration Sessions
  • Care Coordination

Best for: Community & Connection

FREE Consult

Individual Experience

Price: $4,799

A private, one-on-one experience fully tailored to you.

  • Screening
  • 2 Preparation Sessions
  • 1 Psilocybin Session
  • IV Hydration
  • 2 Integration Sessions
  • Care Coordination

Best for: Privacy & Personalized Care

FREE Consult

Premier Signature Neuroplasticity Intensive

Price: Starting at $14,999

Our most comprehensive physician-directed brain health program, combining neurofeedback, psychedelic therapies, precision medicine, and personalized care into one fully integrated experience.

There is no one-size-fits-all protocol. Your physician will build a personalized treatment plan based on your individual needs and goals. The services below are examples of therapies that may be incorporated into your program; some may not be recommended for you, while other treatments or services may be added as appropriate.

Your personalized treatment plan may include:

  • Neurofeedback Therapy Treatment Course
  • One-on-One Physician-Directed Care
  • Multiple Brain Maps & Progress Reviews
  • Advanced Bloodwork & DNA Testing
  • Personalized Supplement Protocol
  • Psilocybin-Assisted Therapy (frequency individualized)
  • Ketamine-Assisted Therapy (frequency individualized)
  • IV Hydration
  • Care Coordination
  • Multiple Provider Visits & Integration Sessions

Best for: Patients seeking the highest level of personalized care through a comprehensive program designed to optimize brain health and support lasting change.

FREE Consult

Not sure which program is right for you? Let's find the best path for your goals. Schedule a free consultation.

Hear from Our Patients

Real experiences. Real perspectives.
Hear directly from patients about their experiences with our team, treatments, and approach to care.

Watch Their Stories

Frequently Asked Questions

  • Is psilocybin therapy legal in Denver?
    Yes—psilocybin services are permitted in Colorado under Proposition 122, approved by voters in 2022. Colorado has established a regulated framework for natural medicine services, with specific requirements for providers, preparation, administration, and client safety.
  • Who is eligible for psilocybin-assisted therapy at PICMI Denver?
    Adults experiencing mood, trauma, or cognitive challenges may be considered for psilocybin-assisted therapy. Eligibility is determined through an individualized medical and mental health screening based on your health history, medications, goals, and overall suitability for treatment.
  • How does psilocybin affect the brain?
    Psilocybin is converted by the body into psilocin, which interacts with serotonin receptors involved in mood, perception, and cognition. This can temporarily change how different brain networks communicate, potentially creating greater flexibility in thoughts, emotions, and perspectives. In a therapeutic setting, these changes may provide an opportunity to explore patterns, gain new insights, and support meaningful change.
  • What conditions can psilocybin-assisted therapy help treat?
    Research has shown promise for psilocybin-assisted therapy in areas including depression, anxiety, PTSD, obsessive-compulsive symptoms, and certain substance use challenges. It may also support emotional resilience, cognitive flexibility, and personal growth when used within an appropriate therapeutic framework.
  • How is psilocybin therapy different from traditional mental health treatments?
    Psilocybin-assisted therapy offers a focused, experiential approach rather than relying solely on daily medication or conventional talk therapy. The experience may temporarily increase psychological flexibility, creating an opportunity to explore emotions, perspectives, and thought patterns with therapeutic support.
  • What does a psilocybin session feel like? Will I hallucinate?
    The experience varies from person to person. Psilocybin can temporarily alter perception, emotions, sensory experiences, thought patterns, and your sense of time. Some people experience vivid visual or sensory effects, while others notice subtler changes. Your mindset, dosage, and environment can all influence the experience.
  • How is psilocybin administered?
    Psilocybin is administered orally during a scheduled session in a controlled, supportive environment. The specific approach and dosage are determined as part of your individualized treatment plan.
  • How long does a psilocybin session last?
    The active effects of psilocybin typically last for several hours, although the duration can vary based on the individual and dose. You should plan to spend a significant portion of the day at the clinic, with your specific schedule provided before treatment.
  • Can I continue taking my current medications?
    It depends on the medication. Some medications can interact with psilocybin or influence the treatment experience, so your physician will review your prescriptions, over-the-counter medications, vitamins, and supplements before treatment. Never stop or change a prescribed medication without medical guidance.
  • How do I prepare for my psilocybin session?
    Preparation includes learning what to expect, discussing your intentions and concerns, and receiving individualized instructions from your care team. You may also receive guidance about medications, food, sleep, transportation, and other practical considerations before your session.
  • What safety measures are in place during psilocybin-assisted therapy at PICMI?
    Safety begins with individualized screening and continues throughout the treatment process. Sessions take place in a controlled setting with appropriate clinical oversight, and patients are supported throughout the experience. Your provider will also review relevant health considerations before treatment.
  • Can I drive after my psilocybin session?
    No. You should arrange transportation home in advance and should not drive immediately after treatment. Psilocybin can temporarily affect perception, attention, judgment, and coordination. Follow your provider's guidance about when it is safe to resume driving.
  • What should I expect after treatment?
    After treatment, you may feel reflective, emotionally open, tired, or energized. Integration and follow-up care help you process the experience and turn meaningful insights into practical changes. Your ongoing support will depend on your individual treatment plan and goals.
  • What is integration therapy and why is it important after psilocybin sessions?
    Integration helps you make sense of your experience and apply meaningful insights to everyday life. Sessions may include reflection, emotional processing, and practical strategies that support continued growth after the psychedelic experience.
  • How do group psilocybin sessions work?
    Group programs are offered on pre-scheduled dates, typically over a weekend, and provide a shared therapeutic environment. They can foster connection and accountability while offering a more accessible option for patients, including those traveling from out of town.

Psilocybin Therapy: Research & News

  • Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report

    A 2026 Frontiers in Neuroscience case report documented unexpected cognitive and functional gains across multiple domains in a patient with advanced Alzheimer's disease after administration of high-dose psilocybin-containing mushrooms — raising new questions about neuroplasticity and psilocybin's potential relevance to neurodegenerative conditions.

    Read the Study

  • Investigating the safety and tolerability of single-dose psilocybin for post-traumatic stress disorder: A nonrandomized open-label clinical trial

    This 2025 nonrandomized open-label trial examined psilocybin's safety profile in adults living with post-traumatic stress disorder. Results indicated the treatment was well-tolerated at a single dose, lending early clinical support for continued investigation into psilocybin as a PTSD intervention.

    Read the Study

  • Therapeutic Use of Psilocybin in Depression: a Systematic Review of Clinical Evidence

    A systematic review from researchers at the Central Institute of Mental Health in Mannheim, published in Acta Neuropsychiatrica, found that one or two psilocybin sessions paired with psychological support produced antidepressant effects that held for weeks to months. Across structured clinical settings, the compound demonstrated a strong tolerability profile.

    Read the Study

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Convenient Location, Parking & Comfortable Care Environment

Our clinic is designed for ease, privacy, and comfort from the moment you arrive. Patients benefit from convenient on-site parking, elevator access, and quiet, climate-controlled treatment spaces. Use the map to plan your visit and experience a setting built to support focused, uninterrupted care.

Real Stories. Real Transformation.

Health and wellness is priceless, and given the current state of our medical system, it's worth it to have a team of amazing medical professionals be available to help me on my health journey.

— C. R.

I had an excellent experience with Premier Integrative & Cognitive Institute. Their team was professional, responsive, and clearly knowledgeable.

— Rachel C.

This clinic is AMAZING!!! The idea behind brain health is soooo innovative! We need this sort of medicine allover. Lynn and her amazing team have done an excellent job preparing this business with all the perfect details.