Psilocybin-Assisted Therapy in Denver
Physician-directed care. Board-certified providers. Medical oversight.Get a $49 Brain ScanFor a limited time only!
A Supportive Environment for Psilocybin-Assisted Therapy
As a licensed healing center in Denver, we provide a supportive, compassionate environment for psilocybin-assisted therapy. We understand that considering any cognitive or mental health treatment can feel daunting, and we want you to know that you are in a safe, welcoming space. Our team of board-certified providers is here to guide you through every step with care, clarity, and respect for your unique journey.
Professional Psilocybin Programs Designed for Safety and Efficacy
Psilocybin-assisted therapy at PICMI is offered as a regulated clinical intervention. This therapy supports adults navigating mood, trauma, or cognitive challenges, and/or seeking personal insight, emotional growth, and enhanced resilience through a medically guided, integrative approach. We blend rigorous clinical oversight with personalized support to ensure a safe, structured, and meaningful experience.
What You Can Expect
- Personalized Screening: We begin by getting to know you, your health history, and your goals to ensure that psilocybin therapy is appropriate, safe, and aligned with your needs.
- Guided Sessions with Professional Oversight: Each experience is carefully facilitated by trained clinicians who provide support, reassurance, and expert guidance throughout the process.
- Integration Support: After each session, we work with you to explore your experiences, helping translate insights into practical tools for emotional clarity, cognitive flexibility, and sustained personal growth.
Why Choose Us
Our team combines advanced training in psychiatry, integrative medicine, and neuroscience with a deep commitment to patient-centered care. We take pride in providing a safe, professional, and welcoming environment where every individual is treated with respect, empathy, and thoughtful guidance.
At PICMI, psilocybin-assisted therapy is a clinically guided journey designed to support healing, self-understanding, and meaningful transformation, all while meeting the highest medical and regulatory standards.
Whether you are exploring therapy for the first time or seeking innovative cognitive or mental health solutions, our Denver-based team is here to walk alongside you with expertise, compassion, and care.
Meet Your Care Team
Lynn Welch Puana, MD
Founder & Medical Director,
Premier Integrative & Cognitive
Medical Institute
Amir Mahmoud, NP, PMHNP-BC
Clinical Director,
Psychiatric-Mental Health
Nurse Practitioner
Nedjet Fenix, DNP, CNM
Licensed Facilitator
John Manasjan, FP-C, NREMT-P
Licensed Psychedelic Facilitator
Adolphus Love, LMT
EEG Technician
Frequently Asked Questions About Psilocybin-Assisted Therapy in Denver
- Is psilocybin therapy legal in Denver?
Yes—psilocybin therapy is permitted in Colorado under Proposition 122, approved in 2022. Denver was an early leader in allowing psilocybin use, and licensed healing centers began opening in 2024. Today, sessions take place in a safe, regulated setting with trained, licensed providers.
- Who is eligible for psilocybin-assisted therapy at PICMI Denver?
Adults experiencing mood, trauma, or cognitive challenges may be considered for psilocybin-assisted therapy. Eligibility is determined through a thorough medical and mental health screening to ensure safety, suitability, and alignment with your treatment goals.
- What conditions can psilocybin-assisted therapy help treat?
Psilocybin therapy has shown promise in supporting treatment-resistant depression, anxiety disorders, PTSD, obsessive-compulsive or rigid thought patterns, and certain substance use challenges. It can also support personal growth, emotional resilience, and cognitive flexibility under professional guidance.
- How is psilocybin therapy different from traditional mental health treatments?
Unlike daily medications or standard therapy alone, psilocybin-assisted therapy provides a focused, experiential approach that temporarily increases neural flexibility. This state allows individuals to explore emotions, trauma, or thought patterns in a deep, guided way, creating opportunities for lasting cognitive and emotional change.
- What safety measures are in place during psilocybin-assisted therapy at PICMI?
Safety is a top priority at PICMI. All sessions are supervised by trained, licensed providers with medical oversight. We conduct personalized screening, monitor vital signs during sessions, and provide psychological support throughout to ensure a safe, structured experience.
- What is integration therapy and why is it important after psilocybin sessions?
Integration therapy helps translate insights gained during psilocybin sessions into practical, lasting change. Our clinicians guide patients through reflective exercises, coping strategies, and emotional processing to reinforce resilience, cognitive flexibility, and overall mental wellness.
- How soon can I expect to notice benefits from psilocybin therapy?
Many patients report noticeable improvements in mood, clarity, or perspective within hours to days after a session. Full benefits often become more apparent over several weeks as insights from therapy are integrated into daily life with professional support.
- Is there research supporting psilocybin therapy for depression, anxiety, or PTSD?
Yes! Clinical studies and systematic reviews show that psilocybin-assisted therapy, combined with structured psychological support, can produce rapid and sustained improvements in depression, anxiety, and trauma-related conditions.
Jump to Research below or visit our blog for ongoing news and updates on psilocybin-assisted therapy.
- Where is PICMI located in Denver and how can I schedule a consultation?
We are located in central Denver at 400 S Colorado Blvd. You can schedule a consultation by calling our office at (303) 946-2333.
Psilocybin Therapy: Research & News
Therapeutic Use of Psilocybin in Depression: a Systematic Review of Clinical Evidence
Psilocybin therapy significantly improved depression symptoms in treatment-resistant patients when delivered under structured clinical guidance, highlighting its potential as a rapid-acting intervention.
Investigating the safety and tolerability of single-dose psilocybin for post-traumatic stress disorder: A nonrandomized open-label clinical trial
A single-dose psilocybin intervention was well-tolerated and linked to meaningful reductions in PTSD symptoms when administered in a supervised clinical setting.
Limited Time Promotion
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